Key studies

The studies below represent some of the groundbreaking work on women and heart disease and stroke. You’ll find information on women’s health issues, prevention strategies and treatment options.

Association of Age and Sex With Myocardial Infarction Symptom Presentation and In-Hospital Mortality

Women are generally older than men at hospitalization for myocardial infarction (MI) and also present less frequently with chest pain/discomfort. However, few studies have taken age into account when examining sex  differences in clinical presentation and mortality.

Gender and Sex Determinants of Circulatory and Respiratory Health

Through the creation of a team of basic science, clinical epidemiological and health services researchers, GENESIS is investigating the sex and gender determinants for the development, presentation, process of care and outcome of cardiovascular disease (CVD) where “gender” determinants are behavioral and environmental factors and “sex” determinants are biological and genetic factors. GENESIS is funded by the Canadian Institutes of Health Research (CIHR) and the Heart and Stroke Foundation of Canada.

Women and Ischemia Syndrome Evaluation (WISE): Summary of Workshop on the Diagnosis and Pathophysiology of Ischemic Heart Disease

Funded by the NHLBI the WISE study provided new insights into sex and gender differences in coronary heart disease. At a workshop sponsored by NHLBI the WISE investigators, together experts in CHD detection and experts in research translation and health communications, came together to provide recommendations for applied research and education in detecting coronary heart disease (CHD) in women. This workshop was planned in collaboration with investigators of major studies /databases to facilitate an interactive forum addressing present research concerns and recommending novel research directions and clinical application. The workshop provided new direction for applied research in CHD in women and an updated science-based message about early recognition of CHD in women.

INTERHEART: Nine factors that could save your life

INTERHEART is a global study led by McMaster University’s Dr. Salim Yusuf that focuses on cardiovascular disease (CVD) and was co-funded by the Canadian Institutes of Health Research (CIHR), the Heart and Stroke Foundation of Ontario and 37 other funding sources. The study involved 15,000 patients with a first acute myocardial infarction (AMI) and 15,000 asymptomatic control subjects (age and sex matched) drawn from 262 centres in 52 countries throughout Asia, Europe, the Middle East, Africa, Australia, and North and South America.